Unlockable: New Game+ Once you beat Story Mode, you'll be able to play through it again with all of your powers and upgrades.
Unlockable: Hard Mode Beat the game on Normal to unlock Hard Mode.
Unlockable: Platinum Earning a Gold in every event unlocks Platinum Events, which are more difficult. Unlockable: Secret Story Event Complete all Scientist Consume events to reveal Karen Parker's location after her disappearance.
Easy Thermobaric Tank First you must unlock the Kill Event called "Rolling Thunder," which appears between the East Village and the Lower East Side (one block from the East coast). Right next to the Event is a Thermobaric Tank. Jumping into it will activate the Event, but you can back out of it before the Event begins. Do this correctly and you'll have a free tank. Note: If you exit the tank it or use it to destroy a Hive or Base it will vanish. You can grab it again at the Event point.
Easy "The Butcher" and "Speed Bumps" Trophy To easily get "The Butcher" Trophy, which requires you to kill 50 people in five seconds (including pedestrians, military, infected etc.), wait until you have the ability to hijack a tank. Drive into a red zone that typically has a lot of fleeing normal and infected civilians and stick to driving on the side walk. Keep up with this same tactic to unlock Speed Bumps, which requires you to run over 500 people in a single tank.
Easy "The Cleaner" Trophy "The Cleaner" Trophy requires you to destroy 10 military bases or infected hives. Choose Hives. Hives are being pummeled by the military by the time you get there, so some of the work is already done. All you have do is finish them off. Hijack a tank and destroy it. NOTE: The hives destroyed during missions count as well.
Easy "Misconception" Achievement and EP The "Misconception" Achievement requires you to destroy 25 infected water towers before they hatch. Do this after you get your powers back -- when Ragland helps you -- as there seem to be more of them in abundance. Lock on to one and run up the corresponding building, jump to the roof and use the flying kick attack, causing more than half of the life bar to be depleted. Upon landing, follow up quickly with a combo. To make it a little faster, use the "claws" powers. Later in the game this becomes even easier. Just hijack a helicopter, fly over infected areas and keep tapping the target button until you target a water tower (or helicopter or Hive) and fire away. The "Friendly Fire" and "Projectiles" Kill Events as both have helicopters sitting next to the Event markers, so grab those and exit the event for a free 'copter.
Easy "Half-Truths" Trophy An easy spot to complete "Half-Truths" is the mission in which you lead the Leader Hunter to Ragland. Complete your objectives unnoticed (shouldn't be a problem) until you are prompted to lure the Hunter. Look at the map and notice that it is mainly covered in red (infected zones) and two blue (military) zones, one on the far east and far west. There is an unclaimed area straight up the middle. Stick to this path and you won't alert the military as they have their hands full already.
Unlimited EP Exploit On mission 22/31, where you get the first cell phone cut scene, you'll be asked to jack a Black ops helicopter. Once you have the helicopter, you are prompted to pick up a few Black Ops guys and then destroy a Hive. Do not destroy the Hive! You now have a helicopter with unlimited missiles, no time limit, and as long as you don't destroy the Hive, you can blow up anything else without it kicking off the alert meter. This also allows you to get out of the helicopter without it ending the mission (useful for collecting Memory Strands). The easiest way to get EP in this is to switch to your Infected Vision and fly around blowing up infected water towers. You can save your game in the middle of this mission if you need a break and do the same thing. You can max out your skills and then some using this exploit.
Mind the Crows Infected water towers are always circled by squawking crows. This makes it easier to track them down.
Collectible Vision It's sometimes difficult to spot Landmark and Hint Collectibles. Switch on your Infected Vision (or Thermal Vision) to help discern them.
Smooth Landing Speed Boost After jumping, avoid using both of your dashes while airborne and save one to use just before landing. If timed correctly, you should hit the ground at near full speed, which is very useful when attempting to evade the military or during a timed activity. Note: This doesn't work for the highest of drops.
Easy "Butcher" Achievment Once you've attained the Critical Mass and Tendril Devastator upgrades, simply choose a disguise (in order to keep a low profile), walk into the middle of Times Square, wait until you are surrounded by people and unleash the Tendril Devastator this will land you "The Butcher."
Final Boss Strategy After the cut scene ends, quickly switch to Armor and Blade (Infected Vision also helps). Stay away from your opponent until he starts to jump after you. When he lands, hit him with the Air Blade Slash. Get in a couple of good hits and he should be stunned. Grab him and repeatedly hit the PUNCH button. If he knocks you down to critical, use a Devastator move to stun him.
Water Disguise If you are near water, and the military is everywhere, then hop into the water and change your disguise immediately as your entire body enters in the water. You'll can then escape unnoticed.
Web of Intrigue Targets Most of the WoI targets will appear randomly, usually while doing a mission or a side mission. But the last few will pop up randomly. It takes forever, so grab a helicopter (using the mission-canceling exploit above) and use it to fly around the city to make things easier.
Flourish Move Once you purchase a power in Prototype and have it set as a shortcut move, you can then hold down the shortcut button to do a flourish move with the power. It's a unique, if useless, animation.
Orb Collecting XP Rewards You'll receive XP for each Orb you pick up. That value is based on how many Orbs you've collected. These values are given below in addition to the one-time bonuses you get for reaching certain Orb collection milestones. Landmark Orbs 1 - 2,600 each 10 - 5,000 each (+10,000 bonus) 25 - 9,750 each (+25,000 bonus) 100 - 15,000 each (+50,000 bonus) 125 - 17, 250 each (+60,000 bonus) 150 - 20,000 each (+70,000 bonus)
Hint Orbs 1 - 5,000 Each 10 - 7,500 each (+10,000 Bonus) 15 - 12,500 each (+25,000 Bonus) 35 - 15,000 each (+50,000 Bonus)
Easy "Trail of Fire" Trophy Using the Thermobaric tank cheat described above, simply circle the hives of infected and fire at the people. Each shot can usually take out 50+ people. Infected Vision is recommended.
Jump to: Codes Hints Trophies
Au (Silver): Achieve a rating of gold or better in all events
Brain Trust (Bronze): Complete all consume events
Children of Blacklight: (Bronze) You've completed the Supreme Hunter Boss Battle
Cleanup (Bronze): Kill 15 characters with a single whipfist attack
Crossing the T (Bronze): Complete the Hunter Boss Encounter
Endless Hunger (Silver): Consume 200 characters to boost your health
Errand Boy (Bronze): You've completed the Specialist Boss Fight
Evolutionary step (Bronze): Use the upgrade menu to acquire an upgrade
Gunning (Bronze): Destroy 20 helicopters in a single helicopter flight
Half-Truths (Bronze): Complete a mission without causing a single military alert
Hard To Kill (Gold): Complete story mode in any difficulty without dying
Hope (Bronze): Discover the truth behind Hope, Idaho through the Web of Intrigue.
In Plain Sight (Bronze): Evade 10 strike teams
In The Web (Bronze): Consume 50 web targets
Infiltrator (Bronze): Infiltrate 10 military bases disguised as a commander
It’s Him! (Bronze): Patsy 5 military personnel
Mankind is your mask (Silver): Complete 3 missions without causing a single military alert
Misconception (Bronze): Destroy 25 infected water towers before they hatch
Nice Guy (Silver): Complete the game while consuming 10 civilians or fewer
On Instinct (Bronze): You've completed the Mother Boss Battle
One Thousand Suns (Bronze): You've completed the Supreme Hybrid Boss Battle
Origin (Bronze): Discover the history of Elizabeth Greene through the Web of Intrigue
Platinum Trophy: Collect all other Prototype trophies
Polymath (Silver): Collect all hint collectibles scattered across New York City
Pt (Gold): Achieve a platinum medal in all events
Repossession (Bronze): Seize 50 vehicles from enemy hands
Return Fire (Bronze): Catch any object tossed by a hydra and throw it back
Revenge Revisited (Gold): Complete story mode on hard difficulty
Self-Deception (Bronze): Discover what happened to Alex Mercer through the web of intrigue
SME (Bronze): Gain the ability to drive and fly all vehicles
Speed Bumps (Bronze): Run over 500 characters in a single tank
Streetwise (Silver): Collect all landmark collectibles scattered across New York City
Surface-To-Air (Bronze): Shoot down 50 helicopters while driving armor
The butcher (Silver): Kill 50 characters in 5 seconds
The Cleaner (Silver): Destroy 10 military bases or infected hives in New York City
The First Thread (Bronze): Unlock the web of intrigue
Threat Elevated (Bronze): Destroy 25 strike teams
Trail Of Corpses (Silver): Kill 53,596 infected
Unnatural Selection (Silver): Acquire all available upgrades
Web Of Knowledge (Gold): Acquire all nodes of the web of intrigue
Wrecking Yard (Bronze): Destroy 2,000 Vehicles
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